Publications by authors named "Amina Amadou"

Article Synopsis
  • Breast cancer is the most common cancer in women, and environmental pollutants, particularly endocrine disruptors like dioxins, may influence its development.
  • A study analyzed the link between airborne dioxin exposure and breast cancer risk in a cohort of 5222 cases and 5222 controls, using data about their proximity to dioxin sources and other factors.
  • The results indicate a slight increase in breast cancer risk with higher cumulative dioxin exposure, suggesting the need for measures to reduce air pollution exposure.
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Background: Growing epidemiological evidence suggests an association between exposure to air pollutants and breast cancer. Yet, the underlying mechanisms remain poorly understood. This study explored the mediating role of thirteen metabolic health biomarkers in the relationship between exposure to three air pollutants, i.

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Background: While genetic, hormonal, and lifestyle factors partially elucidate the incidence of breast cancer, emerging research has underscored the potential contribution of air pollution. Polychlorinated biphenyls (PCBs) and benzo[a]pyrene (BaP) are of particular concern due to endocrine-disrupting properties and their carcinogenetic effect.

Objective: To identify distinct long term trajectories of exposure to PCB153 and BaP, and estimate their associations with breast cancer risk.

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Background: An increasing evidence links air pollution to breast cancer (BC) risk. Yet, pollutant exposure estimates at the workplace location in pollution exposure assessment have not been considered.

Objectives: This study investigates the association between particulate matters (PM, PM) and nitrogen dioxide (NO) atmospheric concentrations (1990-2011), at the women's residential and workplace locations, and BC risk.

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Background: Human exposure to air pollution involves complex mixtures of multiple correlated air pollutants. To date, very few studies have assessed the combined effects of exposure to multiple air pollutants on breast cancer (BC) risk.

Objectives: We aimed to assess the association between combined exposures to multiple air pollutants and breast cancer risk.

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Article Synopsis
  • - The study investigates the combined effects of four air pollutants with endocrine-disrupting properties (benzo-[a]-pyrene, cadmium, dioxin, and PCB153) on breast cancer risk, noting that most research typically looks at each pollutant individually.
  • - Using statistical methods like weighted quantile sum and quantile g-computation, the researchers found a positive association between exposure to pollutant mixtures and increased breast cancer risk, though one method (BKMR) showed less statistical significance.
  • - The findings suggest that joint exposure to these pollutants may contribute to breast cancer risk, with specific pollutants like benzo-[a]-pyrene and cadmium showing stronger associations, while dioxin displayed an inverse trend.
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Current evidence of an association of breast cancer (BC) risk with air pollution exposure, in particular from traffic exhaust, remains inconclusive, and the exposure assessment methodologies are heterogeneous. This study aimed to conduct a systematic review and meta-analysis on the association between traffic-related air pollution (TRAP) and BC incidence (PROSPERO CRD42021286774). We systematically reviewed observational studies assessing exposure to TRAP and BC risk published until June 2022, available on Medline/PubMed and Web of Science databases.

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Background: Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer risk. We investigated the associations of body shape phenotypes with the risk of overall and site-specific cancers.

Methods: We derived four distinct body shape phenotypes from principal component (PC) analysis on height, weight, body mass index (BMI), waist (WC) and hip circumferences (HC), and waist-to-hip ratio (WHR).

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Article Synopsis
  • Long-term exposure to nitrogen dioxide (NO) air pollution is associated with an increased risk of breast cancer, based on a study conducted within the French E3N cohort of 5222 breast cancer cases and matched controls.
  • The study utilized a land use regression model to estimate annual mean concentrations of NO for each participant, finding that each interquartile range increase in NO levels correlated with an odds ratio (OR) of 1.09 for breast cancer risk.
  • Results showed consistent effects for postmenopausal women, while no significant association was found for premenopausal women, suggesting that long-term NO exposure could be a relevant factor in breast cancer risk, particularly for certain demographics.
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Background: Primary liver cancer is common in West Africa due to endemic risk factors. However, epidemiological studies of the global burden and trends of liver cancer are limited. We report changes in trends of the incidence of liver cancer over a period of 28 years using the population-based cancer registry of Bamako, Mali.

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Molecular studies suggest that cadmium due to its estrogenic properties, might play a role in breast cancer (BC) progression. However epidemiological evidence is limited. This study explored the association between long-term exposure to airborne cadmium and risk of BC by stage, grade of differentiation, and histological types at diagnosis.

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In epidemiology, left-truncated data may bias exposure effect estimates. We analyzed the bias induced by left truncation in estimating breast cancer risk associated with exposure to airborne dioxins. Simulations were run with exposure estimates from a Geographic Information System (GIS)-based metric and considered two hypotheses for historical exposure, three scenarios for intra-individual correlation of annual exposures, and three exposure-effect models.

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Background: We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity.

Methods: We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast).

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Background: Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive and developmental toxicant, however epidemiological evidence of the long-term effect of ambient air BaP on breast cancer (BC) is limited. Thus we evaluated associations between ambient air BaP exposure and risk of BC, overall and according to menopausal status and molecular subtypes (estrogen receptor negative/positive (ER-/ER+) and progesterone receptor negative/positive (PR-/PR+)), stage and grade of differentiation of BC in the French E3N cohort study.

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Article Synopsis
  • The study investigates the link between exposure to PCB153, a common environmental pollutant, and the risk of breast cancer, highlighting that genetic and hormonal factors do not fully account for all cases.
  • Researchers analyzed data from over 5,000 breast cancer cases and matched controls within the French E3N cohort, utilizing atmospheric concentration models to estimate cumulative PCB153 exposure for participants.
  • Findings indicate a significant increase in breast cancer risk associated with PCB153 exposure, particularly in postmenopausal women and for ER-positive breast cancer types, suggesting environmental factors may play a crucial role in breast cancer development.
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Article Synopsis
  • Breast cancer is the most common cancer in women in industrialized nations, potentially linked to lifestyle and environmental factors, especially endocrine-disrupting pollutants like air pollutants.
  • * The XENAIR project aims to examine the connection between chronic air pollutant exposure and breast cancer risk, focusing on various pollutants and how factors like menopausal status and hormone receptor status may influence this relationship.
  • * The study will utilize a case-control design within a large French cohort, gathering data through questionnaires and advanced modeling techniques to analyze exposure effects on breast cancer risk and potential genetic interactions.
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Liver cancer (mostly hepatocellular carcinoma, HCC) is both common and highly lethal throughout Africa, in particular in western and middle Africa where HCC is the first cause of cancer death in men and the third in women. In these high-incidence areas, HCC develops mostly early (<50 years), with an aggressive clinical course and frequently without prior diagnosis of liver cirrhosis. The dynamics of African populations predict that the burden of liver cancers will be multiplied by three to four in the next decades unless effective prevention and therapy is achieved.

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Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide. Risk factors for HCC include chronic hepatitis B and hepatitis C, alcohol addiction, metabolic liver disease (particularly nonalcoholic fatty liver disease) and exposure to dietary toxins such as aflatoxins and aristolochic acid. All these risk factors are potentially preventable, highlighting the considerable potential of risk prevention for decreasing the global burden of HCC.

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Cadmium, due to its estrogen-like activity, has been suspected to increase the risk of breast cancer; however, epidemiological studies have reported inconsistent findings. We conducted a case-control study (4,059 cases and 4,059 matched controls) nested within the E3N French cohort study to estimate the risk of breast cancer associated with long-term exposure to airborne cadmium pollution, and its effect according to molecular subtype of breast cancer (estrogen receptor negative/positive [ER-/ER+] and progesterone receptor negative/positive [PR-/PR+]). Atmospheric exposure to cadmium was assessed using a Geographic Information System-based metric, which included subject's residence-to-cadmium source distance, wind direction, exposure duration and stack height.

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Article Synopsis
  • This study investigates the prevalence of harmful TP53 gene variants linked to Li-Fraumeni syndrome (LFS) using the gnomAD dataset, which includes over 138,000 individuals.
  • The researchers found that conservative estimates suggest one in every 3,555 to 5,476 people carries a pathogenic TP53 variant, a significantly higher rate than expected.
  • The results highlight the need for improved methods to assess how these variants relate to cancer risk and the LFS phenotype, as current estimates may not accurately reflect the familial cancer patterns typical of LFS.
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Purpose Of Review: Germline pathogenic TP53 mutation may predispose to multiple cancers but penetrance and cancer patterns remain incompletely documented. We have analyzed international agency for research on cancer TP53 database to reevaluate age and variant-dependent tumor patterns.

Recent Findings: Genome-wide studies suggest that germline variants are more frequent than estimated prevalence of Li-Fraumeni syndrome (LFS), suggesting that many carriers of potentially pathogenic mutations may not develop the syndrome.

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Purpose: Impaired B vitamin status has been identified as a risk factor for major chronic diseases. This study aims at examining the determinants of plasma folate and vitamin B12 concentrations, considering lifestyle factors and MTHFR polymorphisms.

Methods: A total of 988 women aged 40-65 years from the French E3N cohort were investigated.

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Synopsis of recent research by authors named "Amina Amadou"

  • - Amina Amadou's recent research focuses primarily on the relationship between air pollution, particularly specific pollutants like PCBs, benzo[a]pyrene, nitrogen dioxide, and their potential link to breast cancer risk, highlighting the need for comprehensive understanding of exposure impacts over time
  • - The studies utilize innovative statistical methods to assess combined effects of multiple air pollutants on breast cancer, challenging traditional epidemiological approaches which typically evaluate pollutants in isolation
  • - Additionally, Amadou explores the role of body shape phenotypes and anthropometric traits in cancer risk, investigating potential biological pathways, thereby integrating environmental, biological, and lifestyle factors in cancer epidemiology