Using deep learning and pretreatment EEG to predict response to sertraline, bupropion, and placebo.

Objective: Predicting an individual's response to antidepressant medication remains one of the most challenging tasks in the treatment of major depressive disorder (MDD). Our objective was to use the large EMBARC study database to develop an electroencephalography (EEG)-based method to predict response to antidepressant treatment.

Methods: Pre-treatment EEG data were collected from study participants treated with either sertraline (N = 105), placebo (N = 119), or bupropion (N = 35).

Diagnostic deep learning algorithms that use resting EEG to distinguish major depressive disorder, bipolar disorder, and schizophrenia from each other and from healthy volunteers.

Background: Mood disorders and schizophrenia affect millions worldwide. Currently, diagnosis is primarily determined by reported symptomatology. As symptoms may overlap, misdiagnosis is common, potentially leading to ineffective or destabilizing treatment.

A Robust eLORETA Technique for Localization of Brain Sources in the Presence of Forward Model Uncertainties.

Objective: In this paper, we present a robust version of the well-known exact low-resolution electromagnetic tomography (eLORETA) technique, named ReLORETA, to localize brain sources in the presence of different forward model uncertainties.

Methods: We first assume that the true lead field matrix is a transformation of the existing lead field matrix distorted by uncertainties and propose an iterative approach to estimate this transformation accurately. Major sources of the forward model uncertainties, including differences in geometry, conductivity, and source space resolution between the real and simulated head models, and misaligned electrode positions, are then simulated to test the proposed method.

Effect of prolonged direct and indirect peroxide bleaching on fracture toughness of human dentin.

Statement Of The Problem: The effects of prolonged exposure to peroxide bleaching agents on dentin structural integrity are uncertain.

Purpose: To evaluate the effect of in vitro prolonged tooth bleaching on the fracture toughness (K(1C)) of human dentin.

Materials And Methods: Dentin from recently extracted molar teeth was directly or indirectly treated to simulate a prolonged at-home (10% carbamide peroxide or 3% hydrogen peroxide, 6 hours/day, 5 days/week for 8 weeks) or in-office (30% hydrogen peroxide, 1 hour/week for 8 weeks) bleaching regimen (N=8/group).