Publications by authors named "Amin Kraiem"
Background: Solubility is a common feature of allergens. However, the causative relationship between this protein-intrinsic feature and sensitization capacity of allergens is not fully understood. This study aimed to proof the concept of solubility as a protein intrinsic feature of allergens.
View Article and Find Full Text PDFToll-like receptors of the human immune system are specialized pathogen detectors able to link innate and adaptive immune responses. TLR ligands include among others bacteria-, mycoplasma- or virus-derived compounds such as lipids, lipo- and glycoproteins and nucleic acids. Not only are genetic variations in TLR-related genes associated with the pathogenesis of allergic diseases, including asthma and allergic rhinitis, their expression also differs between allergic and non-allergic individuals.
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- Seasonal exposure to birch pollen (BP) triggers allergic reactions, with Toll-like receptor 4 (TLR4) playing a potential role in this process that hasn't been fully understood yet.
- The study investigates how TLR4 affects the activation of dendritic cells (DCs) by birch pollen extracts (BPE) and assesses the contributions of lipopolysaccharides (LPS) and other components in BPE.
- Results indicate that TLR4 is crucial for the activation of mouse and human DCs by BPE, and that this activation influences T cell responses, highlighting the significance of TLR4 in birch pollen-induced allergic inflammation.
Purpose Of Review: Pathogenesis-related class 10 (PR-10) proteins are highly conserved plant proteins, which are induced in response to abiotic and biotic stress factors. To date, no unique biological function could be assigned to them. Rather a more general role of PR-10 in plant development and defense mechanisms has been proposed.
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