Synopsis of recent research by authors named "Amin Kamel"
- Amin Kamel's recent research primarily focuses on the pharmacokinetics, metabolism, and therapeutic potential of oligonucleotide and small molecule drug candidates, exploring their absorption, distribution, metabolism, and excretion (ADME) profiles in different animal models.
- Key findings include the identification of RGLS4326's preferential distribution to the kidney, which demonstrates its potential for treating polycystic kidney disease, and the metabolic pathways involved in the biotransformation of various therapeutic agents, highlighting differences across species.
- Kamel also emphasizes the necessity for tailored guidelines in the development of siRNA therapeutics, given their unique properties compared to small molecules and biologics, thus contributing significant insights into optimizing drug design and preclinical evaluation strategies.
