Three-dimensional modeling of Marfan syndrome with elastic and hyperelastic materials assumptions using fluid-structure interaction.

Background: Marfan syndrome (MFS) is a genetic disorder of the connective tissue. It most prominently influences the skeletal, cardiovascular, and ocular systems, but all fibrous connective tissue throughout the body can be affected as well.

Objective: This study aims to investigate a realistic three-dimensional model of an aorta of a specific patient suffering from MFS by considering elastic and hyperelastic materials for the tissue using fluid-structure interaction (FSI).

Investigating the performance of four specific types of material grafts and their effects on hemodynamic patterns as well as on von Mises stresses in a grafted three-layer aortic model using fluid-structure interaction analysis.

One of the important parts of the cardiac system is aorta which is the fundamental channel and supply of oxygenated blood in the body. Diseases of the aorta represent critical cardiovascular bleakness and mortality around the world. This study aims at investigation of hemodynamic parameters in a two-dimensional axisymmetric model of three-layer grafted aorta using fluid-structure interaction (FSI).