In Situ Casting of Platelet Rich Plasma/SiO2/Alginate for Bone Tissue Engineering Application in Rabbit Mandible Defect Model.

Statement Of The Problem: The administration of both platelet rich plasma (PRP) and silicon dioxide (SiO) to the bone defects accelerates bone repair and regeneration. Appli-cation of both of them may show synergistic regenerative effects.

Purpose: Our objective was to evaluate the possible synergistic osteogenic effects of PRP and SiO by injecting them using an ad hoc device.