Publications by authors named "Amii C Steele"
Background: Medication non-adherence is common among adolescents and young adults (AYAs) with cancer and associated with poor health outcomes. AYAs with cancer endorse multiple barriers to adherence that differ across individuals, suggesting that tailoring intervention content to an AYA's specific barriers may have the potential to improve adherence. The purpose of this manuscript is to report on ORBIT-guided Phase I design efforts to create the first tailored adherence-promotion intervention for AYAs with cancer and the study protocol for the ongoing Phase II pilot feasibility trial.
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- The study aimed to enhance the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic lymphoma (T-LL) by testing the proteasome inhibitor bortezomib and reducing the use of prophylactic cranial radiation (CRT) in newly diagnosed patients.
- In a clinical trial involving over 800 patients, a modified chemotherapy regimen was used, comparing outcomes between patients who received bortezomib and those who did not, with the goal of assessing event-free survival (EFS) and overall survival (OS).
- Results indicated that bortezomib significantly improved EFS and OS for T-LL patients, while allowing a dramatic reduction in CRT usage
Research indicates that a subset of youths with childhood cancer and their parents will experience significant psychological distress throughout the course of their illness. Importantly, the existing literature indicates that psychosocial support is beneficial in decreasing symptoms of distress in these families. The aim of the current review is to determine the extent of the evidence to support a standard of psychosocial care for children and their families throughout the cancer trajectory; thus, we examined the research related to psychosocial outcomes in youth with cancer and their parents.
View Article and Find Full Text PDFThis study examined participation factors in a study of families ( = 84) within 1 year of a child's cancer-related death. Specific aims were to examine associations between: (a) recruitment variables (number of phone calls made to eligible families, number of calls answered by eligible families) and participation rates (study agreement and refusal) and (b) characteristics of deceased children (gender, age, length of illness, time since death) and participation rates. Characteristics of deceased children did not differ between participating and non-participating families.
View Article and Find Full Text PDFObjective: To determine how to improve care for families by obtaining their advice to health care providers and researchers after a child's death from cancer.
Design: Families with a surviving sibling (age, 8 to 17 y) were recruited from cancer registries at 3 hospitals in the United States and Canada 3 to 12 months (M=10.4, SD=3.