Publications by authors named "Amie Woolard"
Cardiovasc Res
March 2024
Article Synopsis
- Gene therapies like TNNT2-4Fpolycistronic-NIL have shown promise in treating subacute ischaemic heart failure (IHF) by inducing cardiomyocyte (CM) cell cycle re-entry but need testing in chronic IHF settings for broader clinical relevance.
- In the study, rats with induced chronic IHF were treated with TNNT2-4Fpolycistronic-NIL, which led to reduced scar size and improved left ventricular function over four months, though it didn't prevent LV dilation associated with chronic IHF.
- The findings suggest that this gene therapy effectively promotes CM regeneration in chronic IHF, highlighting potential new treatment avenues for this widespread condition.
