Synopsis of recent research by authors named "Amie L Holmes"
- Amie L. Holmes' recent research primarily focuses on the cytotoxic and genotoxic effects of heavy metals like cobalt and hexavalent chromium on human lung and skin cells, revealing the potential carcinogenic risks associated with these substances.
- Studies demonstrate that these metals induce significant chromosome instability and can affect DNA repair mechanisms, notably in human lung epithelial and fibroblast cells, emphasizing the need for further investigation into their long-term health effects.
- Holmes' work highlights the comparative sensitivities of different cell types to metal exposure, showing human skin cells may react more severely to particulate and soluble forms of hexavalent chromium than lung cells, suggesting implications for occupational and environmental exposure risks.
