Publications by authors named "Amie Cessay"
Article Synopsis
- Prevalence of occult hepatitis B infection (OBI) in Africa is not well-researched, prompting a study comparing HBsAg-negative individuals with and without advanced liver disease.
- The study found a significantly higher prevalence of OBI among patients with advanced liver disease (18.3%) compared to healthy controls (9.4%), indicating a strong association with increased risk of liver complications.
- The findings suggest that OBI is common and presents a distinct risk for liver disease in The Gambia, highlighting the need for systematic screening in HBsAg-negative liver disease patients and potentially better outcomes from infant hepatitis B vaccination.
The clinical utility of quantifying hepatitis B surface antigen (qHBsAg) levels in African subjects with chronic hepatitis B virus (HBV) infection has been poorly documented. From a multicentre cohort of 944 HBV-infected African patients, we aimed to assess whether qHBsAg alone can accurately identify i) those in a HBeAg-negative chronic HBV infection phase at low risk of liver disease progression and ii) those in need of antiviral therapy according to the 2017 EASL guidelines. We analysed 770 HBV mono-infected treatment-naïve patients, mainly males (61%) from West Africa (92%), median age 35 years (IQR: 30-44), median HBV DNA: 95.
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