A comparison of nefazodone, imipramine, and placebo in patients with moderate to severe depression.

In this sample of moderately to severely depressed outpatients, nefazodone therapy proved superior to placebo. Nefazodone therapy was also associated with fewer dropouts from adverse effects than was imipramine. In view of these efficacy findings as well as the promising side effect and safety profile of nefazodone, further research is warranted to evaluate its therapeutic potential in the treatment of depressive illness.

Zinc levels of serum, hair and urine in homozygous beta-thalassemic subjects under hypertransfusional treatment.

The concentration of zinc in serum, hair and urine has been examined in 92 homozygous beta-thalassemic and 81 control subjects. The results were not statistically different in the subjects of each group studied (thalassemic and control persons of different ages: 1-12, 12-18, and 18-35 years). In the thalassemic children no statistically significant differences were observed between those normally growing and those with impaired growth.

Factors associated with edema of the mammary gland in primigravid dairy heifers.

The severity and anatomical extent of mammary edema (edema) of 73 primigravid Holstein heifers was scored, and certain hormones in peripheral blood plasma were quantified. The objective was to obtain by least-squares analysis of covariance independent estimates of the association of each hormone and other factors with edema scores around first calving. Mammary edema prepartum increased with age of heifer and gestation length, decreased as calf birthweight increased, but was unrelated to seasonal fluctuations in temperature and photoperiod.

Variables associated with peripartum traits in dairy cows. IX. Relationship of season and other factors to blood plasma concentrations of progesterone and the estrogens.

Least-squares associations of month, average daily temperature, photoperiod (h daylight/24 h) and other factors with plasma concentrations of hormones during the prepartum period were examined in 172 Holstein cows and heifers. The data were summarized and expressed as values for prepartum d 7, 4 and 1, which represented the means for d 8 to 6, 5 to 3, and 2 to 0. respectively.

Variables associated with peripartum traits in dairy cows. VII. Hormones, calf traits and subsequent milk yield.

Independent effects of certain partum and peripartum traits on subsequent milk yields (Y) during days 1 to 27 (Y27), 28 to 60 (Y60) and 1 to 200 (Y200) of lactation were estimated from data on 167 Holstein cows and first-calf heifers. The variables were health status, calf sex and covariates (linear, quadratic and cubic) of calf birth weight (CBW), cow age (CA), month of calving code (season) and the peripartum blood plasma concentrations (means of three samples taken from 48 hr prepartum to within 2 hr postpartum) of prolactin (PRL), progesterone (P4), estrone (E1), estradiol-17 beta (E beta) and estradiol-17 alpha (E alpha). Except for Y200 values, the measures of milk yield were positively correlated (P < .

Variables associated with peripartum traits in dairy cows. IV. Seasonal relationships among temperature, photoperiod, and blood plasma prolactin.

Concentrations of prolactin in plasma were measured in 176 dairy cows and heifers from 13 days before calving to 2.5 days after calving over 21 mo. Prolactin averaged 35.

[Preliminary data on activation of the enzyme of the metabolism of phospholipid bases in various areas of the brain].

The scope of this work was to study the effect of imydazole on base-exchange enzymic system in selected cerebral areas. We have previously demonstrated that imydazole was an activator of phosphatidylserine synthesis in slices of caudate nucleus. This effect lacked in the omogenate we had supposed that this activation by imydazole was not directed on base-exchange enzymic system, but was induced by decrease of cellular cyclic nucleotides amount.