The risk of psychiatric disorders in finasteride users with benign prostatic hyperplasia and androgenetic alopecia: A population-based case-control study.

Background: There is a long-standing debate if finasteride, a medication used to treat benign prostatic hyperplasia (BPH) and androgenetic alopecia (AGA), can cause psychiatric side effects.

Objective: The goal of this large-scale population-based study was to determine whether finasteride therapy for BPH and AGA is associated with the emergence of mental health conditions.

Methods: This observational case-control study compared the data from patients with BPH who received finasteride 5 mg daily and patients with AGA who received finasteride 1 mg daily with age- and gender-matched controls.

Parkinson's Disease, Melanoma, and Keratinocyte Carcinoma: A Population-Based Study.

Background: The association between Parkinson's disease (PD) and melanoma is well recognized, but its relationship with non-melanoma skin cancers has not been studied in depth.

Objective: To assess the relationship between PD, and risk of melanoma and keratinocyte carcinoma: squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).

Methods: This historical cohort study used the data of 1.

[PURPURIC MYCOSIS FUNGOIDES].

A 26-year-old female presented with 4-years duration of asymptomatic spots on her left leg. She was otherwise healthy. On examination several purpuric patches up to 3 cm.

Increased Risk of Tinea Pedis and Onychomycosis Among Swimming Pool Employees in Netanya Area, Israel.

Tinea pedis and onychomycosis often co-occur in individuals. A relationship between swimming pools and tinea pedis exists; however, little research has investigated the relationship between onychomycosis, tinea pedis, and swimming pools. This study sought to examine the prevalence of tinea pedis and onychomycosis among swimming pool employees, a population that may be at risk of tinea infections.

An open comparative study of nail drilling as adjunctive treatment for toenail onychomycosis (.).

Introduction Novel treatment regimens are being developed to improve drug penetration through the nail plate. This study investigated the efficacy of nail drilling regimens for the treatment of onychomycosis. Methods Participants were assigned to holes with combination (oral plus topical terbinafine) therapy (Group 1), holes with topical terbinafine (Group 2) or topical terbinafine only (Group 3).

Darier disease in Israel: combined evaluation of genetic and neuropsychiatric aspects.

Background: Darier disease (DD) is a rare genodermatosis caused by heterozygous mutations in the ATP2A2 gene. It has been associated with neuropsychiatric manifestations.

Objectives: To investigate the genetic basis of Israeli patients with DD, and its association with the neuropsychiatric phenotype.

Griseofulvin and Fluconazole Reduce Transmission of Tinea Capitis in Schoolchildren.

Objective: We evaluated the efficacy of griseofulvin and fluconazole in reducing the potential for person-to-person transmission of tinea capitis (TC) in children.

Methods: Children with TC with positive fungal cultures were treated with griseofulvin 25 mg/kg/day (group A) or fluconazole 6 mg/kg/day (group B) for at least 21 days and up to 12 weeks until cure was achieved. Clinical and mycologic examinations occurred before treatment and on days 3, 7, 10, 14, and 21 of treatment.

Increased prevalence of thyroid disorders in patients with new onset alopecia areata.

Background: Several studies have revealed a high prevalence of thyroid disorders in patients with alopecia areata. The aim of the present study was to evaluate the frequency of thyroid function abnormalities and anti-thyroid auto-antibodies in patients with new onset alopecia areata on their first visit to a community dermatology clinic.

Methods: The study included 78 patients with new onset alopecia areata who visited a community dermatology clinic between 2007 and 2011.

When is onychomycosis onychomycosis? A cross-sectional study of fungi in normal-appearing nails.

Background: The presence of fungal organisms in healthy-looking toenails has previously been reported in individuals with a known dermatophyte infection and in those with onycholysis, but has not been extensively studied in individuals who do not present with foot pathology.

Objectives: To determine the prevalence of fungal organisms in the toenails and on the soles of normal-appearing feet.

Methods: Adults who visited a dermatology clinic between June 2012 and February 2013 for concerns unrelated to fungal infection of the nails and feet participated in this study.

"Sunlight is said to be the best of disinfectants"*: the efficacy of sun exposure for reducing fungal contamination in used clothes.

Background: Tinea pedis is a common chronic skin disease; the role of contaminated clothes as a possible source of infection or re-infection has not been fully understood. The ability of ultraviolet light to inactivate microorganisms has long been known and UV is used in many applications.

Objectives: To evaluate the effectivity of sun exposure in reducing fungal contamination in used clothes.

Clinical comparison and complete cure rates of Terbinafine efficacy in affected onychomycotic toenails.

Background: Clinical studies regarding complete cure rate of onychomycosis using oral Terbinafine have a very broad range (14-90%) based solely on response to treatment on the big toenail.

Objective: To evaluate the efficacy of Terbinafine in all affected onychomycotic toenails and, furthermore, to evaluate differences in mycological, clinical and complete cure rate between affected onychomycotic toenails.

Patients And Methods: Inclusion criteria are as follows: distolateralsubungual onychomycotic involvement of the hallux and additional involvement of at least two more toenails of the same foot.

A case series of 46 patients with lichen planopilaris: Demographics, clinical evaluation, and treatment experience.

Background: Lichen planopilaris (LPP) is as a lymphocytic variant of primary cicatricial alopecia.

Objective: To evaluate the demographics, clinical findings, natural history, and response to various treatments of LPP.

Methods: A retrospective review of medical records of all patients with clinical and histopathological diagnoses of LPP.

The effect of domestic laundry processes on fungal contamination of socks.

Tinea pedis is a common chronic skin disease. The role of contaminated clothes as a possible source of reinfection is not fully understood. This study was conducted to evaluate the efficacy of domestic laundering at different temperatures in the eradication of fungal pathogens from contaminated socks.

Treatment of tinea capitis - griseofulvin versus fluconazole - a comparative study.

Objective: To compare the efficacy and safety of fluconazole and griseofulvin in the treatment of tinea capitis.

Patients And Methods: Patients with tinea capitis (n = 113) with positive fungal cultures entered the study. The patients were divided into four groups with different treatment regimes.

Learning disabilities in Darier's disease patients.

Background: Neuropsychiatric features and intellectual difficulties have been reported in studies of Darier's disease. Learning disabilities have never been reported or evaluated systematically in these patients.

Objective: To assess the prevalence of learning disabilities in 76 patients with Darier's disease, and cognitive functioning in 19 of them.

Molecular analysis of Malassezia species isolated from Israeli patients with pityriasis versicolor.

Background: Pityriasis versicolor (PV) is a common superficial fungal infection of the skin caused by Malassezia species. The clinical significance of each of these species is not fully understood. M.

Bacteriological aspects of Darier's disease.

Background: There are no established data on the prevalence of bacterial colonization of lesional skin, nares and perineum in Darier's disease (DD), or its contribution to the clinical manifestations of the disease.

Objective: To determine the prevalence of bacterial colonization of lesional skin and Staphylococcus aureus (S. aureus) in nares and perineum in 75 patients with DD, the association of these parameters with disease and patient characteristics, and the features of the bacterial skin infection in this group.

Onychomycosis: a simpler in-office technique for sampling specimens.

Background: In onychomycosis, proper specimen collection is essential for an accurate diagnosis and initiation of appropriate therapy. Several techniques and locations have been suggested for specimen collection.

Objective: To investigate the optimal technique of fungal sampling in onychomycosis.

Health-related quality of life among Darier's disease patients.

Background: Darier's disease (DD) is an autosomal dominant skin disorder characterized by persistent eruption of hyperkeratotic papules. The effect of DD on quality of life (QOL) has been assessed in only one study, which found no correlation between the Dermatology Life Quality Index (DLQI) score and clinical severity of the disease. The correlation between health-related quality of life (HRQL) and other diseases and patient characteristics has not been studied.

The impact of stratifying initial dose of corticosteroids by severity of pemphigus vulgaris on long-term disease severity.

Background: Pemphigus vulgaris (PV) is a life-threatening disease affecting skin and mucous membranes. The "epitope spreading" theory posits that uncontrolled PV can gradually worsen because of exposure of cellular antigens to the immune system. To this end, high-dose systemic corticosteroids have been advocated as first-line treatment for patients with PV to achieve disease control.

A rationale for systemic treatment in onychomycosis with negative results on fungal examination.

Background: Fungal infection of the nail affects millions of people worldwide, and has an estimated prevalence of about 10% of the general population. Laboratory confirmation of fungal infection is currently accepted as a requirement before initiation of antifungal treatment in clinical practice.

Aim: To examine the rationale for systemic treatment in cases of clinical onychomycosis with negative results on fungal examination (potassium hydroxide test and fungal culture).