All-In-One Magnetic Nanoparticles for Thermo-Immunotherapy of Malignant Melanoma.

Hyperthermia using magnetic nanoparticles is a promising cancer therapy that locally destroys tumors and induces antitumor immunity by releasing tumor antigens from dying cells. However, magnetic hyperthermia in malignant melanomas with poor immunogenicity and an immunosuppressive microenvironment remains challenging. Here, all-in-one magnetic nanoparticles (αPD-L1/CpG@MCL) are developed for thermo-immunotherapy that enables hyperthermia with magnetic nanoparticles and immunotherapy with anti-PD-L1 antibody and CpG to improve the immunosuppressive tumor microenvironment.

Combination of magnetic hyperthermia and immunomodulators to drive complete tumor regression of poorly immunogenic melanoma.

Hyperthermia using magnetic nanoparticles enables tumor-specific heating and can destroy tumor tissues. This approach works as in situ vaccination with tumor antigens released from dying tumor cells. However, in situ vaccination caused by magnetic hyperthermia is often insufficient to induce complete regression of poorly immunogenic tumors surrounded by an immunosuppressive microenvironment.