Publications by authors named "Ami Kurokawa"
Article Synopsis
- Staphylococcal enterotoxin A (SEA) is a superantigen that activates the JAK/STAT signaling pathway by binding to the gp130 receptor, influencing immune response in mouse spleen cells.
- High levels of interferon gamma (IFN-γ) and SOCS1 mRNA were observed after SEA treatment, but these were reduced when cells were treated with EGCG.
- EGCG was found to inhibit the binding of SEA to the gp130 receptor and the subsequent phosphorylation of STAT3, suggesting its potential as a therapeutic agent against SEA's effects.
Staphylococcal enterotoxin A (SEA) functions both as superantigens that stimulate non-specific T cell proliferation as well as potent gastrointestinal toxins. We previously reported that (-)-epigallocatechin gallate (EGCG) binds to SEA. Therefore, the ability of EGCG to inhibit SEA toxin activity was examined.
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