Implementation of Electronic Medical Record Interventions to Maximize Opioid Disposal after Surgery in Routine Clinical Practice.

Background: Despite guideline directed opioid prescribing after surgery, many patients retain excess opioids. Leftover pills increase the risk for misuse, diversion, and dependency. It is unclear whether interventions applied in routine clinical practice can increase excess opioid disposal rates.

Expression and characterization of scFv-6009FV in Pichia pastoris with improved ability to neutralize the neurotoxin Cn2 from Centruroides noxius.

Small single-chain variable fragments (scFv) are promising biomolecules to inhibit and neutralize toxins and to act as antivenoms. In this work, we aimed to produce a functional scFv-6009FV in the yeast Pichia pastoris, which inhibits the pure Cn2 neurotoxin and the whole venom of Centruroides noxius. We were able to achieve yields of up to 31.

The SAMPL9 host-guest blind challenge: an overview of binding free energy predictive accuracy.

We report the results of the SAMPL9 host-guest blind challenge for predicting binding free energies. The challenge focused on macrocycles from pillar[]-arene and cyclodextrin host families, including WP6, and bCD and HbCD. A variety of methods were used by participants to submit binding free energy predictions.

"Social support and stressful life events: risk factors for antenatal depression in nulliparous and multiparous women".

Nulliparous (pregnant women who are giving birth for the first time) and multiparous (women who have multiple children) may have different concerns, which may be associated with risk of antenatal depression. This study aims to examine the role of social support and stressful life events as risk factors for antenatal depression in nulliparous and multiparous women. The sample included 1,524 pregnant women recruited from an obstetrics setting at the end of the first trimester of pregnancy from two Spanish tertiary-care public hospitals.

Investigations into the effects of vaccination and diet composition on post-weaning diarrhea and growth performance in pigs.

Objectives: Pigs often experience slow growth and enteric disease problems during the early post-weaning period. The objectives were to evaluate effects of a live oral vaccine on post-weaning diarrhea under on-farm conditions and to assess impacts of diet composition on growth and enteric health in the early nursery phase of production.

Procedures And Results: In a series of trials, even when enterotoxigenic (ETEC) was present, post-weaning diarrhea was usually associated with other causes and not ETEC.

An overview of the SAMPL8 host-guest binding challenge.

The SAMPL series of challenges aim to focus the community on specific modeling challenges, while testing and hopefully driving progress of computational methods to help guide pharmaceutical drug discovery. In this study, we report on the results of the SAMPL8 host-guest blind challenge for predicting absolute binding affinities. SAMPL8 focused on two host-guest datasets, one involving the cucurbituril CB8 (with a series of common drugs of abuse) and another involving two different Gibb deep-cavity cavitands.

Upregulation of type 1 conventional dendritic cells implicates antigen cross-presentation in multisystem inflammatory syndrome.

Background: Multisystem inflammatory syndrome in children (MIS-C) is an acute, febrile, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated syndrome, often with cardiohemodynamic dysfunction. Insight into mechanism of disease is still incomplete.

Objective: Our objective was to analyze immunologic features of MIS-C patients compared to febrile controls (FC).

Tail-Biting in Pigs: A Scoping Review.

Tail-biting is globally recognized as a welfare concern for commercial swine production. Substantial research has been undertaken to identify risk factors and intervention methods to decrease and understand this vice. Tail-biting appears to be multifactorial and has proven difficult to predict and control.

Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors.

The botulinum neurotoxin, the caustic agent that causes botulism, is the most lethal toxin known to man. The neurotoxin composed of a heavy chain (HC) and a light chain (LC) enters neurons and cleaves SNARE proteins, leading to flaccid paralysis, which, in severe occurrences, can result in death. A therapeutic target for botulinum neurotoxin (BoNT) intoxication is the LC, a zinc metalloprotease that directly cleaves SNARE proteins.

SAMPL7 Host-Guest Challenge Overview: assessing the reliability of polarizable and non-polarizable methods for binding free energy calculations.

The SAMPL challenges focus on testing and driving progress of computational methods to help guide pharmaceutical drug discovery. However, assessment of methods for predicting binding affinities is often hampered by computational challenges such as conformational sampling, protonation state uncertainties, variation in test sets selected, and even lack of high quality experimental data. SAMPL blind challenges have thus frequently included a component focusing on host-guest binding, which removes some of these challenges while still focusing on molecular recognition.

Synthesis and activity of isoleucine sulfonamide derivatives as novel botulinum neurotoxin serotype A light chain inhibitors.

The botulinum neurotoxin (BoNT) is the most lethal protein known to man causing the deadly disease botulinum. The neurotoxin, composed of a heavy (HC) and light (LC) chain, work in concert to cause muscle paralysis. A therapeutic strategy to treat individuals infected with the neurotoxin is inhibiting the catalytic activity of the BoNT LC.

[Education facing risk consumption of alcoholic beverages - A proposal for interdisciplinary action from the health care professional].

Educating and increasing awareness in the consumer to achieve a moderate alcohol consumption is key to promote a healthy lifestyle. Health care professionals (HCP), in particular community pharmacists and Primary Care (PC) physicians and nurses, are key influencers in the education to prevent risk behaviors. A consumer's poor knowledge of concepts such as standard unit, the recommendations on alcohol use, or the alcohol equivalence in the drinks consumed, can lead to a high-risk use, since "alcohol is alcohol" no matter what beverage contains it.

[Tacit Knowledge: Characteristics in nursing practice].

Introduction: Tacit knowledge can be defined as knowledge which is used intuitively and unconsciously, which is acquired through one's experience, characterized by being personal and contextual. Some terms such as 'intuition', 'know how' and 'implicit knowledge' have been used to describe tacit knowledge. Different disciplines in the fields of management or health have studied tacit knowledge, identifying it as a powerful tool to create knowledge and clinical decision-making.

New ways for nursing inspired by the works of Michel de Certeau.

The focus of this article is the life and work of the French thinker Michel de Certeau, here presented as a philosopher of special interest for nursing. Although in some countries he is relatively unknown, international authors from scientific disciplines regard his texts as a fundamental source in the opening of new intellectual perspectives on current global problems. Some nurses have also considered his ideas as a useful aid for reflecting on their professional activities, and their most important research is cited.

Does duration of teat use in first parity affect milk yield and mammary gene expression in second parity?

It was recently shown that a teat that is not used in the first lactation will have a reduced development and milk yield in the second lactation. In the current study, the impact of imposing a suckling period of 2, 7, or 21 d during the first lactation on piglet performance, milk composition, endocrine status, and mammary gene expression of sows in their second lactation was studied. Pregnant Yorkshire gilts were divided into 3 groups according to lactation length: 1) 2-d lactation (2D; = 20), 2) 7-d lactation (7D; = 20), and 3) 21-d lactation (21D; = 21).

Optomechanical Quantum Control of a Nitrogen-Vacancy Center in Diamond.

We demonstrate optomechanical quantum control of the internal electronic states of a diamond nitrogen-vacancy (NV) center in the resolved-sideband regime by coupling the NV to both optical fields and surface acoustic waves via a phonon-assisted optical transition and by taking advantage of the strong excited-state electron-phonon coupling of a NV center. Optomechanically driven Rabi oscillations as well as quantum interferences between the optomechanical sideband and the direct dipole-optical transitions are realized. These studies open the door to using resolved-sideband optomechanical coupling for quantum control of both the atomlike internal states and the motional states of a coupled NV-nanomechanical system, leading to the development of a solid-state analog of trapped ions.

Influence of gonadotrophin-induced first oestrus on gilt fertility.

The aim of this study was to determine the association between the oestrous response of pre-pubertal gilts to gonadotrophin injection or boar exposure and their subsequent farrowing rate and litter size. At 154 days of age, randomly selected pre-pubertal gilts received an intramuscular injection of 400 IU equine chorionic gonadotrophin plus 200 IU human chorionic gonadotrophin (PG600(®) ; Merck Animal Health; n = 181). From the remaining pool of animals not treated with hormones, the first gilts showing signs of oestrus were selected to act as controls (n = 201).

Influence of lactation length and gonadotrophins administered at weaning on fertility of primiparous sows.

The aim of this study was to determine the effect of lactation length and treatment with gonadotrophins at weaning on reproductive performance of primiparous sows. After 3 wk of lactation, primiparous sows were either weaned (W3; n=273) or received a 7-d-old foster litter for a further 14 d of suckling (W5; n=199). At final weaning (3 wk or 5 wk lactation) sows were randomly assigned to receive an injection of 400 IU equine chorionic gonadotrophin plus 200 IU human chorionic gonadotrophin (PG600(®); W3 + P; n=108 and W5 + P; n=96) or no injection (W3; n=165 and W5; n=103).

Patients' opinions about knowing their risk for depression and what to do about it. The predictD-qualitative study.

Background: The predictD study developed and validated a risk algorithm for predicting the onset of major depression in primary care. We aimed to explore the opinion of patients about knowing their risk for depression and the values and criteria upon which these opinions are based.

Methods: A maximum variation sample of patients was taken, stratified by city, age, gender, immigrant status, socio-economic status and lifetime depression.

[Factors influencing research activity of Andalusian nurses and improvement strategies].

Objectives: To identify factors influencing research activity of Andalusian nurses and to find improvement strategies.

Methods: Qualitative research using SWOT analysis (weaknesses, threats, strengths, opportunities). Nurses were selected deliberately in eight groups according to predetermined criteria.

Understanding the suffering of a patient with an illness: signs, context and strategies.

The aim of this study is to understand the suffering of a patient with an illness, by using a secondary research method, that is, a qualitative meta-study. The primary data source of the meta-study includes "biographical reports". This project is based on a case study, in which the first-hand experiences of a patient with an illness were collected.

[Shared security in the healthcare environment: negotiating the meanings of risk].

Some authors affirm that we live in a "risk society" and point through this statement at the awareness of danger that rules our time and legitimates the adoption of surveillance and control measures to guarantee security. Health services are not alien to this trend, though a biomedical instrumental view prevails consigning the individual to a passive position. In the light of Health Anthropology this article proposes a reflection about a kind of behavioural risk which forces the totality of professionals involved, to make negotiation become the central figure of the attention process.

[Personalizing nursing care. An action research approach].

Objectives: To evaluate the nursing care personalization process in hospitalization units.

Methods: An action research was performed at hospitalization units selected by a convenience sample which guaranteed to carry it out. This process took five phases: approach and awareness, induction, interaction, implementation, and systematization.