Publications by authors named "Amelie Wenz"
Article Synopsis
- - Dravet syndrome (DS) is an early-onset epilepsy primarily caused by genetic variants affecting GABAergic interneuron function, with unclear mechanisms at the chromatin level.
- - Researchers used induced pluripotent stem cells (iPSCs) from both DS patients and healthy donors to study the chromatin accessibility changes during GABAergic cell development and how valproic acid (VPA) influences these changes.
- - The findings revealed that DS iPSCs showed altered chromatin dynamics leading to accelerated GABAergic development, and VPA treatment improved the development of some DS iPSC-GABA cells, suggesting potential pathways for personalized epilepsy treatments.
Heparanase is the sole endoglucuronidase that degrades heparan sulfate in the cell surface and extracellular matrix (ECM). Several studies have reported the localization of heparanase in the cell nucleus, but the functional role of the nuclear enzyme is still obscure. Subjecting mouse embryonic fibroblasts (MEFs) derived from heparanase knockout (Hpse-KO) mice and applying transposase-accessible chromatin with sequencing (ATAC-seq), we revealed that heparanase is involved in the regulation of chromatin accessibility.
View Article and Find Full Text PDFUnlabelled: Relapse is the leading cause of death in patients with medulloblastoma, the most common malignant pediatric brain tumor. A better understanding of the mechanisms underlying recurrence could lead to more effective therapies for targeting tumor relapses. Here, we observed that SOX9, a transcription factor and stem cell/glial fate marker, is limited to rare, quiescent cells in high-risk medulloblastoma with MYC amplification.
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