Publications by authors named "Amelie Simonnet"
Article Synopsis
- High-frequency cocaine intake is linked to increased drug-seeking behavior in both humans and animals, but the underlying neurobiology is not fully understood.
- Key brain structures like the medial prefrontal cortex (mPFC), basolateral amygdala (BLA), and nucleus accumbens (NAc) play roles in cocaine seeking, and changes in the immediate early gene c-Fos were studied to explore their contributions.
- The research found that high-frequency cocaine self-administration in rats led to enhanced c-Fos activity in specific mPFC regions, and manipulating these areas affected drug-seeking behavior differently based on the self-administration frequency, suggesting individual variations might influence vulnerability to cocaine addiction.
Cannabinoid type 1 (CB1) receptors control the motivational properties and reinforcing effects of nicotine. Indeed, peripheral administration of a CB1 receptor antagonist dramatically decreases both nicotine taking and seeking. However, the neural substrates through which the cannabinoid CB1 receptors regulate the voluntary intake of nicotine remain to be elucidated.
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