Publications by authors named "Amelie Delaby"
Article Synopsis
- The study investigates the formation of granulomas connected to the resolution of Q fever caused by Coxiella burnetii, revealing that the underlying molecular processes are still not well understood.
- Researchers created human granulomas using peripheral blood mononuclear cells (PBMCs) and C. burnetii-coated beads, finding that over 50% of the altered gene expressions were similar between responses to C. burnetii and BCG extracts, indicating a shared inflammatory pathway.
- The findings highlight that inhibiting specific chemokines like CCL2 and CCL5 hampers granuloma formation, and the unique transcriptional profile of C. burnetii granulomas is significantly tied to the activation of type I interferon
Background: The outcome of Q fever, an infectious disease caused by Coxiella burnetii, is associated with granuloma formation. Granulomas are present in patients with resolutive Q fever but are lacking in patients with chronic Q fever.
Methods: Study of granuloma formation requires invasive approaches.
Image analysis tools are essential to describe and quantify dynamic biological phenomena, such as early stages of granuloma formation. Granulomas are constituted of a collection of immune cells that contain pathogens, leading to their elimination. We presented here a new method to obtain granuloma 3D reconstruction from transmitted light images.
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