Publications by authors named "Amelie Dard"
Article Synopsis
- HOX proteins interact with TALE-class cofactors PBX and MEIS, which helps them regulate gene expression through unique binding motifs.
- The interaction of HOX-PBX complexes usually requires a specific hexapeptide motif, but the presence of MEIS can change this requirement for many HOX proteins.
- The study focused on the human HOXA9 protein's interactions with PBX1 and MEIS1, demonstrating that the binding depends on both a conserved HX motif and specific residues of HOXA9, highlighting the complexity of these protein interactions.
Article Synopsis
- HOX proteins interact with PBX and MEIS cofactors, crucial in development and disease, but the exact nature of these interactions is still not fully understood.
- This study systematically analyzes the interaction properties of HOX, PBX, and MEIS proteins using human and mouse samples, revealing that a key HOX motif is less important when MEIS is present, except for two specific paralog groups.
- The research also uncovers unique, paralog-specific binding sites that vary in their usage and highlight one site's significance in the growth of HOXA7 in breast cancer cells, showcasing the flexible interaction dynamics of HOX proteins with their cofactors.
Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here, we show that Hox proteins are able to interact with a wide range of transcription factors in the live Drosophila embryo.
View Article and Find Full Text PDFDespite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior-posterior axis. Hox proteins exert their function by interaction with TALE transcription factors.
View Article and Find Full Text PDFBackground: Hox proteins are key developmental regulators involved in almost every embryonic tissue for specifying cell fates along longitudinal axes or during organ formation. It is thought that the panoply of Hox activities relies on interactions with tissue-, stage-, and/or cell-specific transcription factors. High-throughput approaches in yeast or cell culture systems have shown that Hox proteins bind to various types of nuclear and cytoplasmic components, illustrating their remarkable potential to influence many different cell regulatory processes.
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