Publications by authors named "Amelie Bouvier"
Article Synopsis
- Immune effector cell-associated neurotoxicity syndrome (ICANS) is a serious complication of CD19-targeted CAR T-cell therapy, and early prediction of patients at risk is crucial for tailored management.
- Elevated serum neurofilament light chain (NfL) levels are linked to the severity of ICANS, with higher levels indicating greater neuroaxonal injury.
- In a study of 150 patients, those with elevated NfL (>75 pg/mL at leukapheresis or >58 pg/mL at infusion) were significantly more likely to develop severe ICANS, suggesting that NfL could be a vital predictive marker for neurotoxicity in CAR T-cell therapy.
Recent studies have highlighted an emerging role for neuro-immune interactions in mediating allergic diseases. Allergies are caused by an overactive immune response to a foreign antigen. The peripheral sensory and autonomic nervous system densely innervates mucosal barrier tissues including the skin, respiratory tract and gastrointestinal (GI) tract that are exposed to allergens.
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