Publications by authors named "Amelia Willett"
Article Synopsis
- - The study presents the first specific reference ranges for electrocardiography (ECG) in laboratory mice, derived from a large dataset of over 26,000 C57BL/6N mice grouped by age and sex.
- - It finds that factors like sex and age have minimal impact on key ECG metrics, while anesthesia significantly reduces heart rate.
- - The reference ranges established for C57BL/6N mice appear applicable to various other mouse strains, providing a crucial resource for research involving cardiac function in experimental settings.
Identifying the genetic determinants of pain is a scientific imperative given the magnitude of the global health burden that pain causes. Here, we report a genetic screen for nociception, performed under the auspices of the International Mouse Phenotyping Consortium. A biased set of 110 single-gene knockout mouse strains was screened for 1 or more nociception and hypersensitivity assays, including chemical nociception (formalin) and mechanical and thermal nociception (von Frey filaments and Hargreaves tests, respectively), with or without an inflammatory agent (complete Freund's adjuvant).
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- - The study investigates the genetic factors underlying congenital heart disease by screening nearly 3,900 mouse gene mutations for cardiac issues, finding 705 lines with conditions like arrhythmia and myocardial hypertrophy.
- - Out of these, 486 genes are newly linked to heart dysfunction, including variants of unknown relevance (VUR), with specific mutations in five genes (Casz1, Dnajc18, Pde4dip, Rnf38, Tmem161b) leading to notable structural heart defects.
- - Using data from the UK Biobank, the research further confirms the role of the DNAJC18 gene in heart function, highlighting its loss as linked to changes in cardiac performance, thus identifying new potential targets for understanding
Aims And Method: To explore whether people from Black, Asian and minority ethnic (BAME) communities experience equality of access and outcome in individual placement and support (IPS) employment services. Cross-sectional data were analysed of all people with severe mental health problems who accessed two mature high-fidelity IPS services in London in 2019 (n = 779 people).
Results: There were no significant differences between the proportions of people who gained employment.