The correlation between positive symptoms and left temporal event-related potentials in the P300 time window is auditory specific and training sensitive.

One of the strongest correlations found between clinical symptoms and a biological index is that between the severity of positive symptoms of schizophrenia and the amplitude of the event-related potential (ERP) in the time window of the P300 deflection at left temporal scalp sites. The functional significance of the ERP component at stake is yet unknown. The present study aims at addressing this issue by testing whether or not the correlation a) is found in both the auditory and the visual modality, b) is restricted to the time window of the P300 deflection, and c) is stable over time.