Publications by authors named "Amelia Schirmer"
Breast cancer (BCa) is the most prevalent type of cancer in women. Several therapies used in the treatment of breast cancer are associated with clinically important rates of cardiovascular toxicity during or after treatment exposure, including anthracyclines. There is a need for new BCa therapeutics and treatments that mitigate chemotherapy-induced cardiotoxicity in BCa.
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- Current prostate cancer therapies improve patient outcomes but lack a cure for advanced cases like mCRPC.
- Research shows that NUAK2 is overexpressed in prostate cancer and correlates with higher metastasis risk, making it a potential target for new treatments.
- Inhibiting NUAK2 in lab studies and patient samples reduced cancer cell growth and tumor progression, suggesting its role as a promising target for further investigation in prostate cancer therapy.
Serine/threonine kinase 3 (STK3) is an essential member of the highly conserved Hippo tumor suppressor pathway that regulates Yes-associated protein 1 (YAP1) and TAZ. STK3 and its paralog STK4 initiate a phosphorylation cascade that regulates YAP1/TAZ inhibition and degradation, which is important for regulated cell growth and organ size. Deregulation of this pathway leads to hyperactivation of YAP1 in various cancers.
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- A significant portion of ocean beaches have undergone nourishment to maintain recreational use and protect shorelines, but this practice alters the original sediment structure.
- Studies in coastal North Carolina have shown that meiofaunal communities, which are tiny organisms living in sediment, have experienced significant changes due to beach nourishment since the early 2000s.
- Comparing current data with historical records indicates that these changes have made beaches more heterogeneous, potentially impacting the ecosystem services provided by these coastal habitats.