Publications by authors named "Amelia Knochel"
Elevated shear stress (ESS) induces vascular remodeling in veins exposed to arterial blood flow, which can lead to arteriovenous (AV) fistula failure. The molecular mechanisms driving remodeling have not been comprehensively examined with a single-cell resolution before. Using an animal mode, single-cell RNA sequencing, and histopathology, we precisely manipulate blood flow to comprehensively characterize all cell subpopulations important during vascular remodeling.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the healing effects of two compounds, avenanthramide (AVN) and β-Glucan, on acute and chronic wounds using a mouse model that mimics human wound healing.
- The results show that both compounds at a 1% dose enhance healing by improving tissue architecture and accelerating recovery time, with AVN reducing inflammation and β-Glucan promoting blood vessel formation.
- Understanding the specific mechanisms of these compounds is crucial for their potential application in human wound care, as they exhibit distinct healing properties.