Publications by authors named "Amelia K Read"
Background: Given its role in the disease pathophysiology, inhibition of vascular endothelial growth factor (VEGF)-mediated angiogenesis has received attention as a potential strategy to reduce epistaxis associated with hereditary hemorrhagic telangiectasia (HHT). In this study we evaluated the efficacy of a submucosal injection of bevacizumab, a VEGF inhibitor, in reducing the severity of epistaxis and improving quality of life when given at the time of operative electrocautery.
Methods: This randomized, double-blinded, placebo-controlled trial was conducted at a single institution from 2014 to 2019.
Article Synopsis
- HPV16 is linked to an increase in head and neck cancers, prompting research into T-cell immune therapies targeting these HPV-related cancers.
- The study identified 16 strong and 29 moderately immunogenic CD8 T-cell epitopes from HPV16 proteins, noting a significant increase in E2-specific T-cell reactivity in HPV-infected patients compared to healthy individuals.
- Findings suggested that T-cell dysfunction in HPV HNSCC is associated with high levels of immune suppressive markers like IDO-1, and combining PD-1 blockade with IDO-1 inhibition improved T-cell responses, highlighting a potential strategy for enhanced immunotherapy against HPV-related head and neck cancers.