Publications by authors named "Amelia H Quach"
J Org Chem
September 2024
Article Synopsis
- Aminated nitrogen heterocycles are important in various chemical fields, especially in drug discovery, but traditional methods for adding nitrogen to them often require complex pre-steps and are mainly restricted to one position (C2).
- The new method introduced allows for direct C-H amination at both C2 and C4 positions of fused azaarenes using a specific I(III) reagent, eliminating the need for preoxidation and enabling higher accessibility for C4 products.
- This technique not only simplifies the process and improves yields, but also offers insights into the mechanism, showcasing a unique way of activating the reagent and explaining the formation of the different amination products.
