Synopsis of recent research by authors named "Amelia H Baker"
- Amelia H Baker's research focuses on the effects of environmental contaminants, particularly organotins like tributyltin (TBT), on bone health and marrow microenvironment, highlighting their role as dual agonists for nuclear receptors linked to bone homeostasis.
- Her studies reveal that TBT exposure negatively impacts osteoblast differentiation, promotes adipogenesis in bone marrow multipotent stromal cells, and alters the bone marrow microenvironment, leading to suppressed B cell development and overall bone quality deterioration.
- Baker's investigations also explore sex-linked differences in the osteogenic and adipogenic differentiation potential of mesenchymal stromal cells, underscoring the importance of understanding intrinsic molecular disparities between male and female MSCs in research on bone formation and aging.
