Publications by authors named "Amelia G White"

Laser usage in veterinary dermatology has increased in popularity over the last several decades. Carbon dioxide (CO) laser is the leading modality in surgical laser for veterinary dermatology because of its unmatched performance with soft tissue, particularly the skin. This laser cuts and coagulates tissue via the photothermal effect of laser energy when interacting with soft tissues with high water content, such as skin.

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  • A 10-year-old spayed female Cavalier King Charles Spaniel was treated for recurrent abscesses, fever, lethargy, and lameness, diagnosed with sterile nodular panniculitis after a thorough investigation.
  • The dog initially improved with immunosuppressive therapy, but after 11 months, she relapsed and had to be euthanized.
  • A postmortem examination revealed a rare case of hyalinizing pancreatic adenocarcinoma linked to pancreatic disease symptoms, which has not been previously reported in dogs.
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  • - The study investigates the effectiveness of fluorescent light energy (FLE), used to treat canine pyoderma, against antibiotic-resistant bacteria Staphylococcus pseudintermedius and Staphylococcus aureus, as no prior in vitro studies exist.
  • - Researchers tested different treatment conditions, including blue light and FLE, on various isolates of S. pseudintermedius and S. aureus, but found no significant antibacterial effects across the treatments.
  • - Despite clinical reports of FLE's effectiveness in treating these infections in animals, the study concludes that its in vitro efficacy is not supported, suggesting a more complex interaction in live animals may contribute to its success.
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Background: Drug interactions are significant considerations for intradermal testing (IDT). Trazodone (TRZ) is an anxiolytic and selective histaminergic (H ) antagonist with no interaction in human prick tests; however, interaction in canine IDT is unknown.

Hypothesis/objectives: Trazodone will not adversely affect intradermal histamine reactions in dogs.

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In collaboration with the American College of Veterinary Pathologists.

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Cutaneous oomycotic infections are a rare dermatological disease primarily affecting horses and dogs. Response to medical management with antifungal therapies is poor because these organisms are not true fungi. Complete cure is unlikely if the infected tissue is unable to be completely surgically excised.

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A 11-year-old male neutered Shih Tzu was referred to a tertiary facility with a history of weight loss, decreased appetite, polydipsia, and lethargy. The dog had a 10-year history of nonspecific allergic dermatitis and was being treated with 16 mg/kg of ketoconazole q12h for Malassezia dermatitis. Vague gastrointestinal signs, hypocholesterolemia, and lack of a stress leukogram increased suspicion for hypoadrenocorticism (HA).

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Background: Meticillin-resistant (MR) staphylococcal pyoderma in dogs has led to increased use of alternate antibiotics such as rifampicin (RFP). However, little information exists regarding its pharmacodynamics in MR Staphylococcus pseudintermedius.

Hypothesis/objectives: To determine the minimum inhibitory concentration (MIC) and killing properties of RFP for canine Staphylococcus pseudintermedius isolates.

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Ciclosporin (CsA) is a common treatment for canine atopic dermatitis (cAD). cAD is a very common skin disease with a multifactorial pathogenesis due to complex interactions between the host and the environment. The purpose of this study was to describe the physical and immunological effects of CsA in cAD using a canine model of AD.

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Embryogenesis is an essential and stereotypic process that nevertheless evolves among species. Its essentiality may favor the accumulation of cryptic genetic variation (CGV) that has no effect in the wild-type but that enhances or suppresses the effects of rare disruptions to gene function. Here, we adapted a classical modifier screen to interrogate the alleles segregating in natural populations of Caenorhabditis elegans: we induced gene knockdowns and used quantitative genetic methodology to examine how segregating variants modify the penetrance of embryonic lethality.

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Background: Terbinafine (TBF) is known to concentrate and persist in human skin. Its use is increasing in veterinary medicine, but there are limited data concerning its tissue concentration and efficacy in dogs.

Hypothesis/objectives: (i) Describe TBF accumulation in canine skin; (ii) Integrate pharmacokinetic data with historical minimum inhibitory concentration (MIC) results for Malassezia pachydermatis to verify the currently used dosage of TBF for the treatment of Malassezia dermatitis.

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Background: Bacterial skin infections are common in dogs and humans. Keratinocytes have phenotypic features of nonprofessional antigen-presenting cells and express various cytokines. However, little is known about the effects of antibiotics on inflammatory markers in canine keratinocytes.

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We present DevStaR, an automated computer vision and machine learning system that provides rapid, accurate, and quantitative measurements of C. elegans embryonic viability in high-throughput (HTP) applications. A leading genetic model organism for the study of animal development and behavior, C.

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We present a hierarchical principle for object recognition and its application to automatically classify developmental stages of C. elegans animals from a population of mixed stages. The object recognition machine consists of four hierarchical layers, each composed of units upon which evaluation functions output a label score, followed by a grouping mechanism that resolves ambiguities in the score by imposing local consistency constraints.

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