Laser usage in veterinary dermatology has increased in popularity over the last several decades. Carbon dioxide (CO) laser is the leading modality in surgical laser for veterinary dermatology because of its unmatched performance with soft tissue, particularly the skin. This laser cuts and coagulates tissue via the photothermal effect of laser energy when interacting with soft tissues with high water content, such as skin.
View Article and Find Full Text PDFBackground: Drug interactions are significant considerations for intradermal testing (IDT). Trazodone (TRZ) is an anxiolytic and selective histaminergic (H ) antagonist with no interaction in human prick tests; however, interaction in canine IDT is unknown.
Hypothesis/objectives: Trazodone will not adversely affect intradermal histamine reactions in dogs.
In collaboration with the American College of Veterinary Pathologists.
View Article and Find Full Text PDFCutaneous oomycotic infections are a rare dermatological disease primarily affecting horses and dogs. Response to medical management with antifungal therapies is poor because these organisms are not true fungi. Complete cure is unlikely if the infected tissue is unable to be completely surgically excised.
View Article and Find Full Text PDFA 11-year-old male neutered Shih Tzu was referred to a tertiary facility with a history of weight loss, decreased appetite, polydipsia, and lethargy. The dog had a 10-year history of nonspecific allergic dermatitis and was being treated with 16 mg/kg of ketoconazole q12h for Malassezia dermatitis. Vague gastrointestinal signs, hypocholesterolemia, and lack of a stress leukogram increased suspicion for hypoadrenocorticism (HA).
View Article and Find Full Text PDFBackground: Meticillin-resistant (MR) staphylococcal pyoderma in dogs has led to increased use of alternate antibiotics such as rifampicin (RFP). However, little information exists regarding its pharmacodynamics in MR Staphylococcus pseudintermedius.
Hypothesis/objectives: To determine the minimum inhibitory concentration (MIC) and killing properties of RFP for canine Staphylococcus pseudintermedius isolates.
Ciclosporin (CsA) is a common treatment for canine atopic dermatitis (cAD). cAD is a very common skin disease with a multifactorial pathogenesis due to complex interactions between the host and the environment. The purpose of this study was to describe the physical and immunological effects of CsA in cAD using a canine model of AD.
View Article and Find Full Text PDFEmbryogenesis is an essential and stereotypic process that nevertheless evolves among species. Its essentiality may favor the accumulation of cryptic genetic variation (CGV) that has no effect in the wild-type but that enhances or suppresses the effects of rare disruptions to gene function. Here, we adapted a classical modifier screen to interrogate the alleles segregating in natural populations of Caenorhabditis elegans: we induced gene knockdowns and used quantitative genetic methodology to examine how segregating variants modify the penetrance of embryonic lethality.
View Article and Find Full Text PDFBackground: Terbinafine (TBF) is known to concentrate and persist in human skin. Its use is increasing in veterinary medicine, but there are limited data concerning its tissue concentration and efficacy in dogs.
Hypothesis/objectives: (i) Describe TBF accumulation in canine skin; (ii) Integrate pharmacokinetic data with historical minimum inhibitory concentration (MIC) results for Malassezia pachydermatis to verify the currently used dosage of TBF for the treatment of Malassezia dermatitis.
Background: Bacterial skin infections are common in dogs and humans. Keratinocytes have phenotypic features of nonprofessional antigen-presenting cells and express various cytokines. However, little is known about the effects of antibiotics on inflammatory markers in canine keratinocytes.
View Article and Find Full Text PDFIEEE Trans Med Imaging
October 2013
We present DevStaR, an automated computer vision and machine learning system that provides rapid, accurate, and quantitative measurements of C. elegans embryonic viability in high-throughput (HTP) applications. A leading genetic model organism for the study of animal development and behavior, C.
View Article and Find Full Text PDFProc IEEE Comput Soc Conf Comput Vis Pattern Recognit
August 2010
We present a hierarchical principle for object recognition and its application to automatically classify developmental stages of C. elegans animals from a population of mixed stages. The object recognition machine consists of four hierarchical layers, each composed of units upon which evaluation functions output a label score, followed by a grouping mechanism that resolves ambiguities in the score by imposing local consistency constraints.
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