Macropinocytosis as a potential mechanism driving neurotropism of .

can invade the central nervous system by crossing the blood-brain barrier via a transcellular mechanism that relies on multiple host factors. In this narrative, we review the evidence that a direct interplay between and brain endothelial cells forms the basis for invasion and transmigration across the brain endothelium. Adherence and internalization of is dependent on transmembrane proteins, including a hyaluronic acid receptor and an ephrin receptor tyrosine kinase.