The gene is involved in Wharton's jelly derived mesenchymal stem cell treatment of Alzheimer's disease in rats.

Introduction: Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer's disease (AD).

Methods: Twenty male adult Wistar rats were randomly distributed into three groups of animals ( = 5). The AlCl group was given 300 mg/kg body weight (BW) of AlCl intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed.

Risk factor of elevated matrix metalloproteinase-3 gene expression in synovial fluid in knee osteoarthritis women.

Introduction: Metalloproteinases-3 (MMP3) are the main enzymes involved in cartilage degradation. Several genetic and non-genetic factors can increase the expression of MMP3 in patients with osteoarthritis (OA). This study aims to analyze the risk factors associated with the expression of the MMP3 gene rs679620 fluid synovial knee OA patients.