Publications by authors named "Amel Clifford"

Article Synopsis
  • The increasing use of peptides and small-molecule drugs in horse racing poses a significant doping risk, as these substances can be difficult to detect and may clear the system quickly after use.
  • This study outlines a new analytical method that can detect over 50 types of peptide-based doping agents and other challenging drugs in horse urine using advanced techniques like LC-MS and solid-phase extraction.
  • Validation results showed that most compounds could be detected at very low concentrations (sub-ng/mL), demonstrating the method's effectiveness and reliability for routine doping tests in equestrian sports.
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Methylphenidate is a powerful central nervous system stimulant with a high potential for abuse in horse racing. The detection of methylphenidate use is of interest to horse racing authorities for both prior to and during competition. The use of hair as an alternative sampling matrix for equine anti-doping has increased as the number of detectable compounds has expanded.

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Zilpaterol is a β -adrenergic agonist and a repartitioning agent that has a high potential for abuse in equine performance athletes. Analysis of zilpaterol in hair is an alternative sampling matrix that extends detection time periods beyond those found in urine or blood samples. Our laboratory has been screening for zilpaterol in hair for many years and recently detected and confirmed its presence in official samples.

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