Publications by authors named "Amel Ait Ali Said"
Article Synopsis
- The study investigates the effects of roscovitine, a drug that inhibits cyclin-dependent kinases, on persistent neutrophilic inflammation in cystic fibrosis (CF), which is driven by chronic pulmonary infections.
- Roscovitine was tested using zebrafish larvae with CF, alongside murine and human models, showing it reduces harmful neutrophil activity and promotes inflammation resolution, but its effectiveness varies across different models.
- While it enhances bacterial killing in human CF macrophages, in animal models, roscovitine led to worsened infections by disrupting immune responses, suggesting careful consideration is needed for its therapeutic use in CF.