Apparent Ultra-High b-Value Diffusion-Weighted Image Reconstruction via Hidden Conditional Random Fields.

A promising, recently explored, alternative to ultra-high b-value diffusion weighted imaging (UHB-DWI) is apparent ultra-high b-value diffusion-weighted image reconstruction (AUHB-DWR), where a computational model is used to assist in the reconstruction of apparent DW images at ultra-high b -values. Firstly, we present a novel approach to AUHB-DWR that aims to improve image quality. We formulate the reconstruction of an apparent DW image as a hidden conditional random field (HCRF) in which tissue model diffusion parameters act as hidden states in this random field.