Publications by authors named "Ameen Haj-Yahia"
Cell Death Dis
January 2024
Article Synopsis
- Osteosarcoma is a rare and aggressive bone cancer that primarily affects younger populations, with poor outcomes and a tendency to spread to the lungs.
- The study utilized a mouse model to investigate the molecular mechanisms behind osteosarcoma by creating single and double knockouts of specific genes (Trp53 and Wwox) and tracking early tumor cell markers.
- Findings indicated that double-knockout cells showed tumor-like characteristics and upregulation of the Myc gene, suggesting it plays a role in the cancer's development, while inhibiting one of its targets (MCM7) reduced cell growth in these double-knockout young bone marrow cells.
