Publications by authors named "Ambra Dell'Orso"
This novel study applies targeted functional proteomics to examine tissues and cells obtained from a cohort of individuals with severe obesity who underwent bariatric surgery (BS), using a Reverse-Phase Protein Array (RPPA). In obese individuals, visceral adipose tissue (VAT), but not subcutaneous adipose tissue (SAT), shows activation of DNA damage response (DDR) markers including ATM, ATR, histone H2AX, KAP1, Chk1, and Chk2, alongside senescence markers p16 and p21. Additionally, stress-responsive metabolic markers, such as survivin, mTOR, and PFKFB3, are specifically elevated in VAT, suggesting both cellular stress and metabolic dysregulation.
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- Bariatric surgery is a way to help people with severe obesity lose weight and improve their health problems.
- A study looked at 36 patients and tested their blood before surgery and 6 and 12 months after, checking over 100 different markers related to health.
- The results showed that besides helping with weight loss and blood sugar early on, the surgery also caused some hidden health risks, like possible inflammation from liver cholesterol changes, which might be ignored when just focusing on weight loss.
Ulmus glabra is a deciduous tree with a wide distribution in the Eurosiberian region. The southernmost populations, in the Mediterranean area, are fragmented in mountain areas which act as a refugium. These small relict populations can act as sentinel of global change, including climate change and impacts of human activities such as air pollution.
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