Mitigation of quorum sensing mediated virulence factors of : the role of Meldrum's acid activated furan.

The rapid emergence of drug resistant pathogens is a major threat which has warranted the development of alternative strategies to combat infectious diseases. In this work, we have tested the anti-virulent activity of Meldrum's acid activated furan (MAF) and 1,3-dimethyl barbituric acid activated furan (BAF) against and . It was found that MAF significantly reduced the violacein production and biofilm formation of at sub-inhibitory concentrations.