Kynurenine pathway alteration in acute pancreatitis and its role as a biomarker of infected necrosis.

Introduction: Infected pancreatic necrosis (IPN) is a major cause of mortality in acute pancreatitis (AP). Currently, no specific strategies are available to predict the development of IPN. Earlier we reported that persistent down-regulation of HLA-DR increases risk of developing IPN.

Pain, depression, and poor quality of life in chronic pancreatitis: Relationship with altered brain metabolites.

Background: To evaluate if altered brain metabolites are connected to pain, depression and affective responses in CP.

Methods: In this prospective study we evaluated pain characteristics, QOL (EORTC QLQc30+PAN28), depression (Beck depression inventory [BDI] II) in 558 patients with CP and 67 healthy controls. Brain metabolites were evaluated using magnetic resonance spectroscopy (MRS) in 49 patients and 5 healthy controls.

Malnutrition after pancreatic enzyme replacement therapy in chronic pancreatitis: Risk factors in real world practice.

Background: RCTs that have shown improvement in coefficient of fat absorption with pancreatic enzyme replacement therapy (PERT) have seldom evaluated the impact on overall nutritional status.

Objective: In this study we evaluated factors responsible for persistence of malnutrition after PERT.

Methods: In this cross-sectional observational study, patients were enrolled based on predefined enrolment criteria.