Publications by authors named "Amber Z Wollam"
Identification of neoantigens is a critical step in predicting response to checkpoint blockade therapy and design of personalized cancer vaccines. This is a cross-disciplinary challenge, involving genomics, proteomics, immunology, and computational approaches. We have built a computational framework called pVACtools that, when paired with a well-established genomics pipeline, produces an end-to-end solution for neoantigen characterization.
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- Manually curated variant knowledgebases are crucial for understanding and sharing information about cancer-related genetic variants, with varying degrees of public access and complexity.
- CIViC is a comprehensive, free cancer variant interpretation database containing over 6,300 curated pieces of evidence for more than 2,300 variants from over 400 genes, promoting wide use in research.
- To improve its clinical application, CIViC emphasizes the need for formal curation guidelines and aims to regularly submit data to ClinVar and seek regulatory approvals for enhanced credibility.