Publications by authors named "Amber Shatzer"
Article Synopsis
- * Ganetespib not only reduced the number of EBV-positive B and T cells, but also affected cellular signaling pathways by decreasing pAkt levels.
- * In research, ganetespib showed potential in delaying EBV-positive lymphomas and improving survival rates in SCID mice, and it also led to a decrease in EBV-positive cells in a patient with T-cell chronic active EBV.
Article Synopsis
- The vaccinia virus mRNA capping enzyme has roles beyond just mRNA capping; it also participates in early viral gene transcription termination and initiation.
- A temperature-sensitive mutant virus (Dts36) shows that the capping enzyme has multifunctional roles, particularly in vivo.
- Biochemical analysis reveals that while two key enzymatic activities (guanylyltransferase and methyltransferase) are compromised in the Dts36 mutant, other activities remain intact, confirming the enzyme's diverse functions.
The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium (Mg(2+)) concentrations. Individuals with genetic deficiencies in MAGT1 have high levels of Epstein-Barr virus (EBV) and a predisposition to lymphoma. We show that decreased intracellular free Mg(2+) causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8(+) T cells and impairs cytolytic responses against EBV.
View Article and Find Full Text PDFAscorbic acid has been shown to kill various cancer cell lines at pharmacologic concentrations. We found that Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) cells were more susceptible to ascorbic acid-induced cell killing than EBV-negative BL cells or EBV-transformed lymphoblastoid cells (LCLs). Ascorbic acid did not induce apoptosis in any of the tested cells but did induce the production of reactive oxygen species and cell death.
View Article and Find Full Text PDFComplementation analysis of the combined Condit/Dales collection of vaccinia virus temperature-sensitive mutants has been reported (Lackner, C.A., D'Costa, S.
View Article and Find Full Text PDFThe heterodimeric vaccinia virus mRNA capping enzyme is a multifunctional enzyme, encoded by genes D1R and D12L. Published biochemical experiments demonstrate that, in addition to mRNA capping, the enzyme is involved in early viral gene transcription termination and intermediate viral gene transcription initiation. This paper presents the phenotypic characterization of Dts36, a temperature sensitive mutant in the large subunit of the mRNA capping enzyme (G705D), encoded by gene D1R.
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