Publications by authors named "Amber M Vandevender"
Article Synopsis
- Megalin (Lrp2) is a crucial receptor in the kidneys that helps reclaim important proteins like albumin, and its absence affects various cellular processes, including SGLT2 expression.
- Deleting Lrp2 in opossum kidney cells led to a significant drop in SGLT2 levels and altered gene expression linked to metabolism and mitochondrial function, while Lrp2 knockout mice showed better glucose tolerance on high-fat diets.
- Interestingly, male Lrp2 KO mice faced kidney damage from a Western-style diet, whereas female counterparts showed less susceptibility, indicating a complex relationship between megalin, diet, and metabolic health.
G-protein coupled receptors (GPCRs) mediate signal transduction from the cellular surface to intracellular metabolic pathways. While the function of many GPCRs has been delineated previously, a significant number require further characterization to elucidate their cellular function. G-protein coupled receptor 19 (GPR19) is a poorly characterized class A GPCR which has been implicated in the regulation of circadian rhythm, tumor metastasis, and mitochondrial homeostasis.
View Article and Find Full Text PDFGrowth differentiation factor 15 (GDF15) is a stress-induced secreted protein whose circulating levels are increased in the context of obesity. Recombinant GDF15 reduces body weight and improves glycemia in obese models, which is largely attributed to the central action of GDF15 to suppress feeding and reduce body weight. Despite these advances in knowledge, the tissue-specific sites of GDF15 production during obesity are unknown, and the effects of modulating circulating GDF15 levels on insulin sensitivity have not been evaluated directly.
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