Depletion of the Microbiota Has a Modest but Important Impact on the Fungal Burden of the Heart and Lungs during Early Systemic Infection in Neutropenic Mice.

The progression and systemic pathobiology of in the absence of a microbiota have not been described. Here, we describe the influence of the microbiota during the first 5 days of infection in germ-free or antibiotic-depleted mice. Depletion of the bacterial microbiota in both germ-free and antibiotic-depleted models results in a modest but important increase in the early stages of infection.