Trends in Substance Use Disorder-related Admissions at a Safety-net Hospital, 2008 - 2020.

Objectives: Safety-net hospitals disproportionately care for people with substance use disorders (SUDs), yet little is known about trends in hospital admissions related to specific substances. This study uses electronic health record data to describe trends in substance-specific admissions at a Midwest urban safety-net hospital.

Methods: We included all admissions from 2008 through 2020 and defined them as non-SUD (N = 154,477) or SUD-related (N = 63,667).

Pathophysiology of the rhesus macaque model for inhalational brucellosis.

The objective of this study was to characterize the rhesus macaque (RM) as a model for inhalational brucellosis in support of the U.S. Food and Drug Administration's (FDA) Animal Rule.

E. coli K-12 and EHEC genes regulated by SdiA.

Background: Escherichia and Salmonella encode SdiA, a transcription factor of the LuxR family that regulates genes in response to N-acyl homoserine lactones (AHLs) produced by other species of bacteria. E. coli genes that change expression in the presence of plasmid-encoded sdiA have been identified by several labs.

Methods in cell-to-cell signaling in Salmonella.

Many bacteria can sense their population density. This has been termed "quorum sensing." The bacteria use this information to coordinate their behavior, essentially behaving as multicellular organisms.

Effect of sdiA on biosensors of N-acylhomoserine lactones.

Many gram-negative bacteria synthesize N-acylhomoserine lactones (AHLs) and then use transcription factors of the LuxR family to sense and respond to AHL accumulation in the environment; this phenomenon is termed quorum sensing. Bacteria produce a variety of AHLs, and numerous bacterial reporter strains, or biosensors, that can detect subsets of these molecules have been constructed. Many of these are based on Escherichia coli because this species does not produce AHLs.