The effects of concentric and eccentric training in murine models of dysferlin-associated muscular dystrophy.

Introduction: Dysferlin-deficient murine muscle sustains severe damage after repeated eccentric contractions.

Methods: With a robotic dynamometer, we studied the response of dysferlin-sufficient and dysferlin-deficient mice to 12 weeks of concentrically or eccentrically biased contractions. We also studied whether concentric contractions before or after eccentric contractions reduced muscle damage in dysferlin-deficient mice.