Publications by authors named "Amber L Mosely"
Article Synopsis
- Ewing sarcoma is a cancer primarily affecting children and young adults, driven by the fusion protein EWSR1::FLI1, which disrupts normal chromatin function and gene regulation.
- Researchers developed a high-throughput screening platform to identify small molecules that can modify chromatin accessibility, leading to the discovery of MS0621, which suppresses the growth of Ewing sarcoma cells through cell cycle arrest.
- MS0621 was found to interact with both RNA splicing and chromatin regulatory proteins in an RNA-independent manner, suggesting it alters chromatin activity and offers a promising target for future treatments based on chromatin dysregulation mechanisms.
Background: Pancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to making advances in therapeutic efficacy. Redox factor-1 (Ref-1), a redox signaling protein, regulates the conversion of several transcription factors (TFs), including HIF-1α, STAT3 and NFκB from an oxidized to reduced state leading to enhancement of their DNA binding.
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