Hyaluronidase: a review of approved formulations, indications and off-label use in chronic pain management.

Importance Of The Field: Hyaluronidase for injection is an adjuvant that increases the absorption and dispersion of other injected drugs or fluids (hypodermoclysis); and improves absorption of radiopaque agents in subcutaneous urography. Ovine hyaluronidase is approved for the treatment of vitreous hemorrhages.

Areas Covered In This Review: We review approved indications for injectable hyaluronidase and off-label uses as well as safety, efficacy and dosing information.