Publications by authors named "Amber Dewitt"
Front Aging Neurosci
September 2022
Article Synopsis
- Mitochondrial bioenergetics, which are essential for cellular energy production, are altered in patients with Alzheimer's disease, specifically affecting those with normal cognition, mild cognitive impairment, and dementia.
- The study measured mitochondrial respiration differences in blood cells from participants, finding that those with dementia showed significantly lower bioenergetics compared to those with normal cognition.
- Analysis of lipid metabolites in the participants' plasma revealed that glycocholic acid (GCA) was lower and linoleic acid (LA) was higher in dementia patients, suggesting these lipids may influence energy metabolism and cognitive status.
Alzheimers Dement
April 2023
Article Synopsis
- Researchers discovered that mitochondrial dysfunction in blood cells can indicate cognitive decline in Alzheimer's disease (AD) patients.
- The study found that people with dementia had the lowest mitochondrial function in their blood cells, while those with mild cognitive impairment (MCI) showed higher oxygen use compared to healthy individuals.
- Blood-based assessments of mitochondrial function could serve as a non-invasive method to track bioenergetic changes related to AD risk and progression over time.
