Systematic analysis of drug combinations against Gram-positive bacteria.

Drug combinations can expand options for antibacterial therapies but have not been systematically tested in Gram-positive species. We profiled ~8,000 combinations of 65 antibacterial drugs against the model species Bacillus subtilis and two prominent pathogens, Staphylococcus aureus and Streptococcus pneumoniae. Thereby, we recapitulated previously known drug interactions, but also identified ten times more novel interactions in the pathogen S.

How the gut microbiota helps keep us vitaminized.

Balanced intestinal retinoic acid concentrations are essential to maintain immune homeostasis in the gut. In this issue of Cell Host & Microbe, Bonakdar et al, sheds light on metabolic host-microbiota interactions and elegantly links diet, microbiota and host functions at the molecular level in the context of vitamin A metabolism.