Publications by authors named "Amaxsell Thiago Barros Souza"
Article Synopsis
- * The analysis included 15 randomized clinical trials involving 2,186 pregnant women and found that nifedipine was generally more effective than magnesium sulfate, although both drugs similarly prolonged pregnancy by 48 hours in some cases.
- * Magnesium sulfate had more side effects than nifedipine, and further research is needed to confirm these findings through large-scale studies.
Efficacy and safety of pembrolizumab in cervical cancer: Protocol for systematic review and meta-analysis of randomized clinical trials.
Dary Medeiros Dantas Amaxsell Thiago Barros de Souza Juliana Dantas de Araújo Santos Camargo Ana Paula Ferreira Costa Ayane Cristine Alves Samento
PLoS One
October 2024
Article Synopsis
- This paper outlines a protocol for a systematic review and meta-analysis to assess the effectiveness and safety of pembrolizumab, either alone or with other treatments, in adult women with cervical carcinoma starting from stage IB2.
- The review will follow PRISMA-P guidelines and search multiple databases and grey literature sources, focusing on randomized clinical trials that evaluate pembrolizumab's impact on cervical cancer outcomes.
- The results will be analyzed and presented to provide quality evidence that can help inform clinical decisions regarding the use of pembrolizumab in this patient population.
Laser therapy for genitourinary syndrome of menopause: systematic review and meta-analysis of randomized controlled trial.
Lisieux de Lourdes Martins Nóbrega Pessoa Amaxsell Thiago Barros de Souza Ayane Cristine Alves Sarmento Ana Paula Ferreira Costa Isis Kelly Dos Santos
Rev Bras Ginecol Obstet
October 2024
Article Synopsis
- - This meta-analysis reviewed randomized controlled trials to evaluate the effectiveness and safety of laser therapy (specifically CO2 and Er:YAG lasers) for treating genitourinary syndrome of menopause (GSM) in women.
- - A total of 12 studies with over 5,000 participants were included, showing that CO2-laser therapy significantly improved vaginal health and reduced symptoms like pain during intercourse, dryness, and burning.
- - Despite the positive outcomes, the evidence's reliability is considered low, which means laser therapy for GSM cannot be strongly recommended at this time.
Introduction: Ivermectin is a drug with antiviral properties and has been proposed as an alternative treatment for patients with COVID-19, in some countries; however, there is limited evidence to support its clinical use. Accordingly, the aim of this review and meta-analysis is to obtain superior evidence on the effectiveness and safety of ivermectin in treatment of COVID-19.
Methods And Analysis: We will search in the medical databases and International Clinical Trials Registry Platform databases for randomised clinical trials and quasi-randomised trials published from December 2019.