ACE Gene I/D Polymorphism and Cardiometabolic Risk Factors: A Cross Sectional Study of Rural Population.

The D allele has been identified as being linked to cardiovascular disease since the discovery of an insertion/deletion (I/D) polymorphism in the ACE gene, this polymorphism has been found to have significant associations with a variety of cardiovascular risk factors. Recent findings indicate a rising prevalence of metabolic disorders among rural populations in developing nations. Research on health matters has been predominantly focused on urban populations, with relatively less attention given to their rural counterparts Hence, the present study attempts to estimate the prevalence of ACE gene I/D polymorphism and explore its association with various cardiovascular risk factors among Rural Yadav population from India.

Single Molecule Study of the Polymerization of RecA on dsDNA: The Dynamics of Individual Domains.

In the , RecA plays a central role in the recombination and repair of the DNA. For homologous recombination, RecA binds to ssDNA forming a nucleoprotein filament. The RecA-ssDNA filament searches for a homologous sequence on a dsDNA and, subsequently, RecA mediates strand exchange between the ssDNA and the dsDNA.

Scavenging of OH and OOH radicals by polyradicals of small polycyclic aromatic hydrocarbons.

The hydroxyl and peroxyl radicals, particularly the former, occur abundantly and damage almost all types of materials. Polycyclic aromatic hydrocarbons (PAHs) and their polyradicals (all hydrogens removed) have been considered as models for graphene in some recent studies. Geometries of different adducts of polyradicals of two small PAHs having four and nine benzene rings with an OH or OOH radical each were optimized employing unrestricted density functional theory and two different density functionals.

Optimal trapping stability of Escherichia coli in oscillating optical tweezers.

Single-beam oscillating optical tweezers can be used to trap rod-shaped bacterial cells and align them with their long axis lying within the focal plane. While such configuration is useful for imaging applications, the corresponding imaging resolution is limited by the fluctuations of the trapped cell. We study the fluctuations of four of the coordinates of the trapped cell, two for its center of mass position and two for its angular orientation, showing the way they depend on the trap length and the trapping beam power.

Z-ring Structure and Constriction Dynamics in .

The Z-ring plays a central role in bacterial division. It consists of FtsZ filaments, but the way these reorganize in the ring-like structure during septation remains largely unknown. Here, we measure the effective constriction dynamics of the ring.

Polyradicals of polycyclic aromatic hydrocarbons as finite size models of graphene: highly open-shell nature, symmetry breaking, and enhanced-edge electron density.

Properties of polyradicals (all CH bonds dissociated) of benzene and certain polycyclic aromatic hydrocarbons (PAHs) were studied. The occurrence of symmetry breaking is revealed in going from benzene and the PAHs to their polyradicals. Polyradicals would serve as finite size models of graphene with unpassivated edges in a more realistic way than the PAHs.

Modeling the activity of glutathione as a hydroxyl radical scavenger considering its neutral non-zwitterionic form.

Glutathione is an immensely important antioxidant, particularly in the central nervous system. The scavenging mechanism of glutathione towards the OH radical was studied theoretically, considering its neutral, non-zwitterionic form relevant to acidic media. Gibbs free barrier and released energies involved in hydrogen abstraction from the different sites of glutathione by an OH radical were studied at the B3LYP/6-31G(d,p), B3LYP/AUG-cc-pVDZ, M06/AUG-cc-pVDZ, M06-2X/AUG-cc-pVDZ levels of density functional theory.