Virtual Lung Screening Trial (VLST): An Replica of the National Lung Screening Trial for Lung Cancer Detection.

Importance: Clinical imaging trials are crucial for evaluation of medical innovations, but the process is inefficient, expensive, and ethically-constrained. Virtual imaging trial (VIT) approach addresses these limitations by emulating the components of a clinical trial. An rendition of the National Lung Screening Trial (NCLS) via Virtual Lung Screening Trial (VLST) demonstrates the promise of VITs to expedite clinical trials, reduce risks to subjects, and facilitate the optimal use of imaging technologies in clinical settings.